Learning Genetic Perturbation Effects at Single-Cell Resolution for Virtual Cells

Jiaqi Zhang examines how computational models can learn the effects of genetic interventions from single-cell experiments. Such experiments reveal causal relationships, but their high-dimensional measurements are costly to collect and difficult to interpret.

The seminar connects identifiable causal representations with a predictive method for previously unseen perturbations. The approach incorporates prior biological knowledge and changes in data distributions to estimate responses at individual-cell resolution. It also uses predictions to guide subsequent experiments. An application identifies and experimentally validates previously unknown T-cell regulators with potential relevance to cancer immunotherapy. The recording follows the original July seminar; the series lists Zhang at MIT, while the recording biography describes her incoming Columbia appointment.