Learning Genetic Perturbation Effects at Single-Cell Resolution for Virtual Cells
Jiaqi Zhang · MIT at the seminar; incoming Assistant Professor, Columbia University
Tue, Jul 14, 2026 · 14:30 UTC
Jiaqi Zhang examines how computational models can learn the effects of genetic interventions from single-cell experiments. Such experiments reveal causal relationships, but their high-dimensional measurements are costly to collect and difficult to interpret. The seminar connects identifiable causal representations with a predictive method for previously unseen perturbations. The approach incorporates prior biological knowledge and changes in data distributions to estimate responses at individual-cell resolution. It also uses predictions to guide subsequent experiments. An application identifi