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Causal relationships

3 seminars

Newest first

Learning Genetic Perturbation Effects at Single-Cell Resolution for Virtual Cells

Jiaqi Zhang · MIT at the seminar; incoming Assistant Professor, Columbia University

…Such experiments reveal causal relationships, but their high-dimensional measurements are costly to collect and difficult to interpret. The seminar connects identifiable causal representations with a predictive method for previously unseen perturbations. The approach incorporates prior biological knowledge and changes in data distributions to estimate responses at individual-cell resolution. It also uses predictions to guide subsequent experiments. An application identifi

Tue, Jul 14, 2026 · 14:30 UTC

Computational Biology

Which nodes in a brain network causally influence one another, and how do such interactions utilize the underlying structural connectivity? One of the fundamental goals of neuroscience is to pinpoint such causal relations. Conventionally, these relationships are established by manipulating a node while tracking changes in another node. A causal role is then assigned to the first node if this intervention led to a significant change in the state of the tracked node. In this presentation, I use a series of intuitive thought experiments to demonstrate the methodological shortcomings of the curren

Wed, Jul 6, 2022 · 15:30 UTC

Computational Neuroscience