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Novel Tools Spatial Temporal

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Seminar✓ Recording AvailableNeuroscience

Novel Tools for Spatial and Temporal Genomics

Fei Chen

Dr

Broad Institute

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Sunday, November 22, 2020

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Sunday, November 22, 2020

12:00 PM Europe/London

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Host: Imperial Centre for Neurotechnology

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Imperial Centre for Neurotechnology

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Abstract

The precise spatial localization of molecular signals within tissues richly informs the mechanisms of tissue formation and function. Here, we’ll introduce Slide-seq, a technology which enables transcriptome-wide measurements with near-single cell spatial resolution. We’ll describe recent experimental and computational advances to enable Slide-seq in biological contexts in biological contexts where high detection sensitivity is important. More broadly, we’ll discuss the promise and challenges of spatial transcriptomics for tissue genomics. Lastly, we’ll touch upon novel molecular recording technologies, which allows recording of the absolute time dynamics of gene expression in live systems into DNA sequences.

Topics

absolute time dynamicsdetection sensitivitygene expressionmolecular recordingslide-seqspatial genomicsspatial transcriptomicstemporal genomicstissue formationtranscriptome

About the Speaker

Fei Chen

Dr

Broad Institute

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Personal Website

www.insitubiology.org

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