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Role Orexin Hypocretin Social

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SeminarPast EventNeuroscience

The role of orexin/hypocretin in social behaviour

Derya Sargin

Dr.

The Hotchkiss Brain Institute, Alberta Children’s Hospital Research Institute University of Calgary

Schedule
Sunday, March 7, 2021

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Sunday, March 7, 2021

12:00 PM Canada/Central

Host: Manitoba Neuroscience Network

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Manitoba Neuroscience Network

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Abstract

My lab is focused on how brain encodes and modulates social interactions. Intraspecific social interactions are integral for survival and maintenance of society among all mammalian species. Despite the importance of social interactions, we lack a complete understanding of the brain circuitry involved in processing social behaviour. My lab investigates how the hypothalamic orexin (hypocretin) neurons and their downstream circuits participate in social interaction behaviours. These neurons are located exclusively in the hypothalamus that regulates complex and goal-directed behaviours. We recently identified that orexin neurons differentially encode interaction between familiar and novel animals. We are currently investigating how chronic social isolation, a risk factor for the development of social-anxiety like behaviours, affects orexin neuron activity and how we can manipulate the activity of these neurons to mitigate isolation-induced social deficits.

Topics

anxiety-like behavioursbrain circuitrychronic social isolationhypocretinhypothalamusneuronal activityorexinsocial behavioursocial interactionssocial isolation

About the Speaker

Derya Sargin

Dr.

The Hotchkiss Brain Institute, Alberta Children’s Hospital Research Institute University of Calgary

Contact & Resources

Personal Website

sarginlab.com

@d_sargin

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twitter.com/d_sargin

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