Single-Cell Multiomics: Phenotypic Plasticity in Colorectal Cancer Metastasis

Investigate cell-state plasticity in primary colorectal tumours and liver metastases using single-cell multiomics and spatial transcriptomics. The presentation examines regenerative and inflammatory states at invasive tumour edges, their regulation by AP-1 and NF-κB, and signals from stromal and immune cells. The findings connect state, location and regulatory mechanisms with possible strategies to limit metastasis and treatment resistance.