SeminarPast EventNeuroscience

Top-down control of neocortical threat memory

Schedule
Wednesday, November 12, 2025
16:00 UTC
Prof. Dr. Johannes Letzkus

Universität Freiburg, Germany

Host: LOOPS de Hoz - Hechavarria

Event Information

Host

LOOPS de Hoz - Hechavarria

Duration

70 minutes

Abstract

Accurate perception of the environment is a constructive process that requires integration of external bottom-up sensory signals with internally-generated top-down information reflecting past experiences and current aims. Decades of work have elucidated how sensory neocortex processes physical stimulus features. In contrast, examining how memory-related-top-down information is encoded and integrated with bottom-up signals has long been challenging. Here, I will discuss our recent work pinpointing the outermost layer 1 of neocortex as a central hotspot for processing of experience-dependent top-down information threat during perception, one of the most fundamentally important forms of sensation.

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