What is hippocampal sclerosis? A cell-type specific perspective

Temporal lobe epilepsy is considered a neuronal microcircuit dysfunction, yet mechanisms are poorly understood. Here we will discuss recent data on cell-type specific alterations of hippocampal microcircuit function in experimental models of temporal lobe epilepsy. We will highlight the importance of leveraging on cellular heterogeneity to better understand the complexities accompanying hippocampal sclerosis.