Theoretical
theoretical neuroscience
SISSA cognitive neuroscience PhD
Up to 2 PhD positions in Cognitive Neuroscience are available at SISSA, Trieste, starting October 2024. SISSA is an elite postgraduate research institution for Maths, Physics and Neuroscience, located in Trieste, Italy. SISSA operates in English, and its faculty and student community is diverse and strongly international. The Cognitive Neuroscience group (https://phdcns.sissa.it/) hosts 6 research labs that study the neuronal bases of time and magnitude processing, visual perception, motivation and intelligence, language, tactile perception and learning, and neural computation. Our research is highly interdisciplinary; our approaches include behavioural, psychophysics, and neurophysiological experiments with humans and animals, as well as computational, statistical and mathematical models. Students from a broad range of backgrounds (physics, maths, medicine, psychology, biology) are encouraged to apply. The selection procedure is now open. The application deadline is 27 August 2024. Please apply here (https://www.sissa.it/bandi/ammissione-ai-corsi-di-philosophiae-doctor-posizioni-cofinanziate-dal-fondo-sociale-europeo), and see the admission procedure page (https://phdcns.sissa.it/admission-procedure) for more information. Note that the positions available for the Fall admission round are those funded by the "Fondo Sociale Europeo Plus", accessible through the first link above. Please contact the PhD Coordinator Mathew Diamond (diamond@sissa.it) and/or your prospective supervisor for more information and informal inquiries.
SISSA Neuroscience department
The Neuroscience Department of the International School for Advanced Studies (SISSA; https://www.sissa.it/research/neuroscience) invites expressions of interest from scientists from various fields of Neuroscience for multiple tenure-track positions with anticipated start in 2025. Ongoing neuroscience research at SISSA includes cognitive neuroscience, computational and theoretical neuroscience, systems neuroscience, molecular and cellular research as well as genomics and genetics. The Department intends to potentiate its activities in these fields and to strengthen cross-field interactions. Expressions of interest from scientists in any of these fields are welcome. The working and teaching language of SISSA is English. This is an equal opportunity career initiative and we encourage applications from qualified women, racial and ethnic minorities, and persons with disabilities. Candidates should have a PhD in a relevant field and a proven record of research achievements. A clear potential to promote and lead research activities, and a specific interest in training and supervising PhD students is essential. Interested colleagues should present an original and innovative plan for their independent future research. We encourage both proposals within existing fields at SISSA as well as novel ideas outside of those or spanning various topics and methodologies of Neuroscience. SISSA is an international school promoting basic and applied research in Neuroscience, Mathematics and Physics and dedicated to the training of PhD students. Lab space and other resources will be commensurate with the appointment. Shared facilities include cell culture rooms, viral vector facilities, confocal microscopes, animal facilities, molecular and biochemical facilities, human cognition labs with EEG, TMS, and eye tracking systems, mechatronics workshop, and computing facilities. Agreements with national and international MRI scanning facilities are also in place. SISSA encourages fruitful exchanges between neuroscientists and other researchers including data scientists, physicists and mathematicians. Interested colleagues are invited to send a single pdf file including a full CV, a brief description of past and future research interests (up to 1,000 words), and the names of three referees to neuro.search@sissa.it. Selected candidates will be invited for an online or in-person seminar and 1- on-1 meetings in summer/autumn 2024. Deadline: A first evaluation round will consider all applications submitted before 15 May 2024. Later applications might be considered if no suitable candidates have been identified yet.
Eugenio Piasini
Up to 6 PhD positions in Cognitive Neuroscience are available at SISSA, Trieste, starting October 2024. SISSA is an elite postgraduate research institution for Maths, Physics and Neuroscience, located in Trieste, Italy. SISSA operates in English, and its faculty and student community is diverse and strongly international. The Cognitive Neuroscience group (https://phdcns.sissa.it/) hosts 7 research labs that study the neuronal bases of time and magnitude processing, visual perception, motivation and intelligence, language and reading, tactile perception and learning, and neural computation. Our research is highly interdisciplinary; our approaches include behavioural, psychophysics, and neurophysiological experiments with humans and animals, as well as computational, statistical and mathematical models. Students from a broad range of backgrounds (physics, maths, medicine, psychology, biology) are encouraged to apply. This year, one of the PhD scholarships is set aside for joint PhD projects across PhD programs within the Neuroscience department (https://www.sissa.it/research/neuroscience). The selection procedure is now open. The application deadline is 28 March 2024. To learn how to apply, please visit https://phdcns.sissa.it/admission-procedure . Please contact the PhD Coordinator Mathew Diamond (diamond@sissa.it) and/or your prospective supervisor for more information and informal inquiries.
Prof. KongFatt Wong-Lin
Postdoctoral Research Associate Position in Computational Neuroscience (Computational Modelling of Decision Making) Applications are invited for an externally funded Postdoctoral Research Associate position at the Intelligent Systems Research Centre (ISRC) in Ulster University, UK. The successful candidate will develop and apply computational modelling, and theoretical and analytical techniques to understand brain and behavioural data across primate species, and to apply biologically based neural network modelling to elucidate mechanisms underlying perceptual decision-making. The duration of the position is 24 months, from January 2024 till end of 2025. The personnel will be based at the ISRC in Ulster University, working with Prof. KongFatt Wong-Lin and his team, while collaborating closely with international collaborators in the USA and the Republic of Ireland, namely, Prof. Michael Shadlen at Columbia University (USA), Prof. Stephan Bickel at Northwell-Hofstra School of Medicine (USA), Prof. Redmond O'Connell at Trinity College Dublin (Ireland), Prof. Simon Kelly at University College Dublin (Ireland), and Prof. S. Shushruth at University of Pittsburgh (USA). The ISRC is dedicated to developing a bio-inspired computational basis for AI to power future cognitive technologies. This is achieved through understanding how the brain works at multiple levels, from cells to cognition and apply that understanding to create models and technologies that solve complex issues that face people and society. All applicants should hold a degree in in Computational Neuroscience, Computational Biology, Neuroscience, Computing, Engineering, Mathematics, Data Science, Physical Sciences, Biology, or a cognate area. Apply online: https://my.corehr.com/pls/coreportal_ulsp/erq_jobspec_version_4.display_form?p_company=1&p_internal_external=E&p_display_in_irish=N&p_applicant_no=&p_recruitment_id=023762&p_process_type=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y Closing date for receipt of completed applications: 8th November 2023. Job Ref: 023762. For any informal enquiries regarding this position, please contact KongFatt Wong-Lin; email: k.wong-lin@ulster.ac.uk ; website: https://www.ulster.ac.uk/staff/k-wong-lin
SueYeon Chung, Center for Computational Neuroscience, Flatiron Institute
Flatiron Research Fellow (Postdoctoral Fellow), NeuroAI and Geometric Data Analysis Description Applications are invited for Flatiron Research Fellowships (FRF) in the NeuroAI and Geometric Data Analysis Group (SueYeon Chung, PI) at the Center for Computational Neuroscience at the Flatiron Institute of the Simons Foundation, whose focus is on understanding computation in the brain and artificial neural networks by: (1) analyzing geometries underlying neural or feature representations, embedding and transferring information, and (2) developing neural network models and learning rules guided by neuroscience. To do this, the group utilizes analytical methods from statistical physics, machine learning theory, and high-dimensional statistics and geometry.The CCN FRF program offers the opportunity for postdoctoral research in areas that have strong synergy with one or more of the existing research groups at CCN or other centers at the Flatiron Institute. In addition to carrying out an independent research program, Flatiron Research Fellows are expected to: disseminate their results through scientific presentations, publications, and software release, collaborate with other members of the CCN or Flatiron Institute, and participate in the scientific life of the CCN and Flatiron Institute by attending seminars, colloquia, and group meetings. Flatiron Research Fellows may have the opportunity to organize workshops and to mentor graduate and undergraduate students. The mission of CCN is to develop theories, models, and computational methods that deepen our knowledge of brain function — both in health and in disease. CCN takes a “systems" neuroscience approach, building models that are motivated by fundamental principles, that are constrained by properties of neural circuits and responses, and that provide insights into perception, cognition and behavior. This cross-disciplinary approach not only leads to the design of new model-driven scientific experiments, but also encapsulates current functional descriptions of the brain that can spur the development of new engineered computational systems, especially in the realm of machine learning. CCN’s current research groups include computational vision (Eero Simoncelli, PI), neural circuits and algorithms (Dmitri ‘Mitya’ Chklovskii, PI), neuroAI and geometric data analysis (SueYeon Chung, PI), and statistical analysis of neural data (Alex Williams, PI), and is planning to expand the number of research groups in the near term. Interested candidates should review the CCN public website for specific information on CCN’s research areas. Applicants who are interested in a joint appointment between two CCN research groups should submit the same application to both groups, noting the dual application in their research statement. Please note that Alex William’s statistical analysis of neural data group is not recruiting at CCN in 2023. FRF positions are two-year appointments and are generally renewed for a third year, contingent on performance. FRF receive a research budget and have access to the Flatiron Institute’s powerful scientific computing resources. FRF may be eligible for subsidized housing within walking distance of the CCN. Review of applications for positions starting between July and October 2024 will begin in November 2023. For more information about life at the Flatiron Institute, visit https://www.simonsfoundation.org/flatiron/careers.
Gatsby Computational Neuroscience Unit
The Gatsby Computational Neuroscience Unit welcomes applications for its PhD Programme in Theoretical Neuroscience and Machine Learning (September 2024 entry). Students complete a 4-year PhD in either machine learning or theoretical neuroscience, with minor emphasis in the complementary field. Courses in the first year provide a comprehensive introduction to both fields and systems neuroscience, with multidisciplinary training in other areas of neuroscience also available. Students are encouraged to work and interact closely with researchers at the Sainsbury Wellcome Centre for Neural Circuits and Behaviour as well as the Centre for Computational Statistics and Machine Learning to take full advantage of the multidisciplinary research environment. PhD research topics can focus on (but not limited to): Graphical models, Kernel methods, Bayesian statistics, Reinforcement learning, Network and relational data, Neural data analysis, Neural representations, Computation and dynamics, Learning, Neural systems. Full funding is available regardless of nationality and current residence.
Cognitive Neuroscience PhD program @ SISSA
Up to 6 PhD positions in Cognitive Neuroscience are available at SISSA, Trieste, starting October 2023. SISSA is an elite postgraduate research institution for Maths, Physics and Neuroscience, located in Trieste, Italy. SISSA operates in English, and its faculty and student community is diverse and strongly international. The Cognitive Neuroscience Department (https://phdcns.sissa.it/) hosts 7 research labs that study the neuronal bases of time and magnitude processing, visual perception, motivation and intelligence, language and reading, tactile perception and learning, and neural computation. The Department is highly interdisciplinary; our approaches include behavioural, psychophysics, and neurophysiological experiments with humans and animals, as well as computational, statistical and mathematical models. Students from a broad range of backgrounds (physics, maths, medicine, psychology, biology) are encouraged to apply. The selection procedure is now open. The first application deadline is 31 March 2023. To learn how to apply, please visit https://phdcns.sissa.it/admission-procedure. Please contact the PhD Coordinator Mathew Diamond (diamond@sissa.it) and/or your prospective supervisor for more information and informal inquiries.
Sainsbury Wellcome Centre, UCL
Applications are now open for the 2023 intake to our PhD Programme at the Sainsbury Wellcome Centre at University College London (UCL). This fully-funded 4-year programme offers students: • a comprehensive introduction to theoretical and systems neuroscience • intensive training in experimental techniques, including imaging, physiology, molecular, and behavioural methods in systems neuroscience • a supportive and collaborative environment with teaching by SWC faculty together with colleagues at the Gatsby Computational Neuroscience Unit and other affiliated institutions Based in central London, with the highest concentration of neuroscience research in the world, SWC students are fully funded and receive an annual stipend of £24,278, as well as funds to attend international courses or meetings. We also cover the cost of tuition fees for both home and international students. The SWC PhD programme is an opportunity to receive world-class training as a neuroscientist and launch an exciting career in academia or industry. Apply to join our pool of exceptional students from around the globe. More information on the SWC PhD programme, and details on how to apply, can be found on the website: https://www.sainsburywellcome.org/web/content/neuroscience-phd-programme If you have any queries about the SWC PhD programme, or the application process, please contact us: SWC-PhDprogramme@ucl.ac.uk.
Prof. John Murray
The Swartz Program for Theoretical Neuroscience at Yale University invites applications for up to two postdoctoral positions in Theoretical and Computational Neuroscience, with flexible start date in 2022. Competitive candidates include those with a strong quantitative background who wish to gain neuroscience research experience. We especially encourage candidates with an interest in collaborating directly with experimental neuroscientists. The candidates will be expected to perform theoretical/computational studies relevant to one or more laboratories of the Swartz Program at Yale and will be encouraged to participate in an expanding quantitative biology environment at Yale. More details here: https://neurojobs.sfn.org/job/31363/postdoctoral-swartz-fellowship-positions-in-theoretical-and-computational-neuroscience-at-yale/
Dr. HernánLópez-Schier
The López-Schier laboratory is looking for PhD candidates to join a multidisciplinary research project that combines experimental and computational neuroscience. The aim of the project is to understand the neuronal bases of spatial navigation. The project is fully funded and part of a consortium of experimental and theoretical neuroscientists in Germany, France and the USA. We are looking for outstanding, highly motivated and ambitious candidates with a solid background in physics, engineering, computer science, or theoretical neuroscience, and a genuine interest in animal behaviour. The positions are fully funded with ideally start in March-June 2021. You will join a multidisciplinary team at the Helmholtz Zentrum in Neuherberg-Munich, Germany. A good command of the English language is necessary. Other requirements are computer programming skills, and good understanding machine learning and machine vision. The Helmholtz Zentrum München is world-renowned for its fundamental research and is among the top research institutions in the world. Munich is cosmopolitan city with a lively lifestyle and outstanding outdoors. Candidates must send their application including a brief letter of interest, a complete CV, as well as contact information of two or three academic references to Dr. Hernan Lopez-Schier
Dr. Gabriele Scheler
We are offering a research stipend to investigate theories of memorization in neural plasticity. The focus is a critical evaluation of the role of LTP/LTD and synaptic plasticity in memory. This position is virtual and could be done part-time, or full-time for three months. The ideal candidate should have solid knowledge of neurobiology, especially plasticity mechanisms, excellent communication skills, interest and enthusiasm for next-generation neural theories, a good understanding of computation and mathematics. Programming skills are not required for this position. Detailed knowledge of one area of neural plasticity, such as synapses, intracellular pathways or genetics, is expected. Further information available on request.
Mario Dipoppa
The selected candidates will be working on questions addressing how brain computations emerge from the dynamics of the underlying neural circuits and how the neural code is shaped by computational needs and biological constraints of the brain. To tackle these questions, we employ a multidisciplinary approach that combines state-of-the-art modeling techniques and theoretical frameworks, which include but are not limited to data-driven circuit models, biologically realistic deep learning models, abstract neural network models, machine learning methods, and analysis of the neural code.
Yashar Ahmadian
The postdoc will work on a collaborative project between the labs of Yashar Ahmadian at the Computational and Biological Learning Lab (CBL), and Zoe Kourtzi at the Psychology Department, both at the University of Cambridge. The project investigates the computational principles and circuit mechanisms underlying human visual perceptual learning, particularly the role of adaptive changes in the balance of cortical excitation and inhibition resulting from perceptual learning. The postdoc will be based in CBL, with free access to the Kourtzi lab in the Psychology department.
Prof. Jean-Pascal Pfister
The project aims at answering an almost 100 year old question in Neuroscience: “What are spikes good for?”. Indeed, since the discovery of action potentials by Lord Adrian in 1926, it has remained largely unknown what the benefits of spiking neurons are, when compared to analog neurons. Traditionally, it has been argued that spikes are good for long-distance communication or for temporally precise computation. However, there is no systematic study that quantitatively compares the communication as well as the computational benefits of spiking neuron w.r.t analog neurons. The aim of the project is to systematically quantify the benefits of spiking at various levels. The PhD students and post-doc will be supervised by Prof. Jean-Pascal Pfister (Theoretical Neuroscience Group, Department of Physiology, University of Bern).
John D. Murray
The Swartz Program for Theoretical Neuroscience at Yale University invites applications for up to two postdoctoral positions in Theoretical and Computational Neuroscience, with flexible start date in 2022. Competitive candidates include those with a strong quantitative background who wish to gain neuroscience research experience. We especially encourage candidates with an interest in collaborating directly with experimental neuroscientists. The candidates will be expected to perform theoretical/computational studies relevant to one or more laboratories affiliated with the Swartz Program at Yale.
I-Chun Lin
The Gatsby Unit seeks to appoint a new principal investigator with an outstanding record of research achievement and an innovative research programme in theoretical neuroscience or machine learning at any academic rank. In theoretical neuroscience, we are particularly interested in candidates who focus on the mathematical underpinnings of adaptive intelligent behaviour in animals, or develop mathematical tools and models to understand how neural circuits and systems function. In machine learning, we seek candidates who focus on the mathematical foundations of learning from data and experience, addressing fundamental questions in probabilistic or statistical machine learning and understanding; areas of particular interest include generative or probabilistic modelling, causal discovery, reinforcement learning, theory of deep learning, and links between these areas and neuroscience or cognitive science.
I-Chun Lin
The Gatsby Computational Neuroscience Unit is offering a 4-year PhD Programme in Theoretical Neuroscience and Machine Learning. The programme provides a unique opportunity for a critical mass of theoreticians to interact closely with one another, with the Sainsbury Wellcome Centre for Neural Circuits and Behaviour (SWC), with the Centre for Computational Statistics and Machine Learning (CSML), and with other research groups in related UCL departments. Students complete a 4-year PhD in either machine learning or theoretical neuroscience, with minor emphasis in the complementary field. Courses in the first year, taught with colleagues from the SWC and CSML, provide a comprehensive introduction to both fields and systems neuroscience. Students are encouraged to work and interact closely with researchers at the SWC and/or CSML to take advantage of this uniquely multidisciplinary research environment.
Boris Gutkin
A three-year post-doctoral position in theoretical neuroscience is open to explore the mechanisms of interaction between interoceptive cardiac and exteroceptive tactile inputs at the cortical level. We aim to develop and validate a computational model of cardiac and of a somatosensory cortical circuit dynamics in order to determine the conditions under which interactions between exteroceptive and interoceptive inputs occur and which underlying mechanism (e.g., phase-resetting, gating, phasic arousal,..) best explain experimental data. The postdoctoral fellow will be based at the Group for Neural Theory at LNC2, in Boris Gutkin’s team with strong interactions with Catherine Tallon-Baudry’s team. LNC2 is located in the center of Paris within the Cognitive Science Department at Ecole Normale Supérieure, with numerous opportunities to interact with the Paris scientific community at large, in a stimulating and supportive work environment. Group for Neural Theory provides a rich environment and local community for theoretical neuroscience. Lab life is in English, speaking French is not a requirement. Salary according to experience and French rules. Starting date is first semester 2024.
Bruno A. Olshausen
The Helen Wills Neuroscience Institute together with the Department of Statistics at UC Berkeley is conducting a faculty search in the area of computational or theoretical neuroscience. This is an ideal opportunity for computational/theoretical neuroscientists who are engaged in both model and theory development and collaborative work with experimentalists.
Boris Gutkin, Catherine Tallon-Baudry
A three-year post-doctoral position in theoretical neuroscience is open to explore the mechanisms of interaction between interoceptive cardiac and exteroceptive tactile inputs at the cortical level. We aim to develop data-based computational models of cardiac and somatosensory cortical circuit dynamics. Building on these models we will determine the conditions under which interactions between exteroceptive and interoceptive inputs occur and which underlying mechanisms (e.g., phase-resetting, gating, phasic arousal,..) best explain experimental data.
Professor Geoffrey J Goodhill
The Department of Neuroscience at Washington University School of Medicine is currently recruiting investigators with the passion to create knowledge, pursue bold visions, and challenge canonical thinking as we expand into our new 600,000 sq ft purpose-built neurosciences research building. We are now seeking a tenure-track investigator at the level of Assistant Professor to develop an innovative research program in Theoretical/Computational Neuroscience. The successful candidates will join a thriving theoretical/computational neuroscience community at Washington University, including the new Center for Theoretical and Computational Neuroscience. In addition, the Department also has world-class research strengths in systems, circuits and behavior, cellular and molecular neuroscience using a variety of animal models including worms, flies, zebrafish, rodents and non-human primates. We are particularly interested in outstanding researchers who are both creative and collaborative.
Helena Dalmau Felderhoff
The Max Planck Institutes for Biological Cybernetics and Intelligent Systems as well as the AI Center in Tübingen & Stuttgart (Germany) offer up to 10 students at the Bachelor or Master level paid three-months internships during the summer of 2024. Successful applicants will work with top-level scientists on research projects spanning machine learning, electrical engineering, theoretical neuroscience, behavioral experiments, robotics and data analysis. The CaCTüS Internship is aimed at young scientists who are held back by personal, financial, regional or societal constraints to help them develop their research careers and gain access to first-class education. The program is designed to foster inclusion, diversity, equity and access to excellent scientific facilities. We specifically encourage applications from students living in low- and middle-income countries which are currently underrepresented in the Max Planck Society research community.
Jorge Jaramillo
The Grossman Center for Quantitative Biology and Human Behavior at the University of Chicago seeks outstanding applicants for multiple postdoctoral positions in computational and theoretical neuroscience. Appointees will join as Grossman Center Postdoctoral Fellows, with the freedom to work with any of its faculty members. We especially welcome applicants who develop computational models and machine learning analysis methods to study the brain at the circuits, systems, or cognitive levels. The current faculty members of the Grossman Center to work with are: Brent Doiron, Jorge Jaramillo, and Ramon Nogueira. Appointees will have access to state-of-the-art facilities and multiple opportunities for collaboration with exceptional experimental labs within the Department of Neurobiology, as well as other labs from the departments of Physics, Computer Sciences, and Statistics. The Grossman Center offers competitive postdoctoral salaries in the vibrant and international city of Chicago, and a rich intellectual environment that includes the Argonne National Laboratory and the Data Science Institute. The Grossman Center is currently engaged in a major expansion that includes the incorporation of several new faculty members in the next few years.
N/A
A post-doctoral position in theoretical neuroscience is open to explore the impact of cardiac inputs on cortical dynamics. Understanding the role of internal states in human cognition has become a hot topic, with a wealth of experimental results but limited attempts at analyzing the computations that underlie the link between bodily organs and brain. Our particular focus is on elucidating how the different mechanisms for heart-to-cortex coupling (e.g., phase-resetting, gating, phasic arousal,..) can account for human behavioral and neural data, from somatosensory detection to more high-level concepts such as self-relevance, using data-based dynamical models.
Haim Sompolinsky, Kenneth Blum
The Swartz Program at Harvard University seeks applicants for a postdoctoral fellow in theoretical and computational neuroscience. Based on a grant from the Swartz Foundation, a Swartz postdoctoral fellowship is available at Harvard University with a start date in the summer or fall of 2024. Postdocs join a vibrant group of theoretical and experimental neuroscientists plus theorists in allied fields at Harvard’s Center for Brain Science. The Center for Brain Science includes faculty doing research on a wide variety of topics, including neural mechanisms of rodent learning, decision-making, and sex-specific and social behaviors; reinforcement learning in rodents and humans; human motor control; behavioral and fMRI studies of human cognition; circuit mechanisms of learning and behavior in worms, larval flies, and larval zebrafish; circuit mechanisms of individual differences in flies and humans; rodent and fly olfaction; inhibitory circuit development; retinal circuits; and large-scale reconstruction of detailed brain circuitry.
“Brain theory, what is it or what should it be?”
n the neurosciences the need for some 'overarching' theory is sometimes expressed, but it is not always obvious what is meant by this. One can perhaps agree that in modern science observation and experimentation is normally complemented by 'theory', i.e. the development of theoretical concepts that help guiding and evaluating experiments and measurements. A deeper discussion of 'brain theory' will require the clarification of some further distictions, in particular: theory vs. model and brain research (and its theory) vs. neuroscience. Other questions are: Does a theory require mathematics? Or even differential equations? Today it is often taken for granted that the whole universe including everything in it, for example humans, animals, and plants, can be adequately treated by physics and therefore theoretical physics is the overarching theory. Even if this is the case, it has turned out that in some particular parts of physics (the historical example is thermodynamics) it may be useful to simplify the theory by introducing additional theoretical concepts that can in principle be 'reduced' to more complex descriptions on the 'microscopic' level of basic physical particals and forces. In this sense, brain theory may be regarded as part of theoretical neuroscience, which is inside biophysics and therefore inside physics, or theoretical physics. Still, in neuroscience and brain research, additional concepts are typically used to describe results and help guiding experimentation that are 'outside' physics, beginning with neurons and synapses, names of brain parts and areas, up to concepts like 'learning', 'motivation', 'attention'. Certainly, we do not yet have one theory that includes all these concepts. So 'brain theory' is still in a 'pre-newtonian' state. However, it may still be useful to understand in general the relations between a larger theory and its 'parts', or between microscopic and macroscopic theories, or between theories at different 'levels' of description. This is what I plan to do.
The Brain Prize winners' webinar
This webinar brings together three leaders in theoretical and computational neuroscience—Larry Abbott, Haim Sompolinsky, and Terry Sejnowski—to discuss how neural circuits generate fundamental aspects of the mind. Abbott illustrates mechanisms in electric fish that differentiate self-generated electric signals from external sensory cues, showing how predictive plasticity and two-stage signal cancellation mediate a sense of self. Sompolinsky explores attractor networks, revealing how discrete and continuous attractors can stabilize activity patterns, enable working memory, and incorporate chaotic dynamics underlying spontaneous behaviors. He further highlights the concept of object manifolds in high-level sensory representations and raises open questions on integrating connectomics with theoretical frameworks. Sejnowski bridges these motifs with modern artificial intelligence, demonstrating how large-scale neural networks capture language structures through distributed representations that parallel biological coding. Together, their presentations emphasize the synergy between empirical data, computational modeling, and connectomics in explaining the neural basis of cognition—offering insights into perception, memory, language, and the emergence of mind-like processes.
Bernstein Student Workshop Series
The Bernstein Student Workshop Series is an initiative of the student members of the Bernstein Network. It provides a unique opportunity to enhance the technical exchange on a peer-to-peer basis. The series is motivated by the idea of bridging the gap between theoretical and experimental neuroscience by bringing together methodological expertise in the network. Unlike conventional workshops, a talented junior scientist will first give a tutorial about a specific theoretical or experimental technique, and then give a talk about their own research to demonstrate how the technique helps to address neuroscience questions. The workshop series is designed to cover a wide range of theoretical and experimental techniques and to elucidate how different techniques can be applied to answer different types of neuroscience questions. Combining the technical tutorial and the research talk, the workshop series aims to promote knowledge sharing in the community and enhance in-depth discussions among students from diverse backgrounds.
Bernstein Student Workshop Series
The Bernstein Student Workshop Series is an initiative of the student members of the Bernstein Network. It provides a unique opportunity to enhance the technical exchange on a peer-to-peer basis. The series is motivated by the idea of bridging the gap between theoretical and experimental neuroscience by bringing together methodological expertise in the network. Unlike conventional workshops, a talented junior scientist will first give a tutorial about a specific theoretical or experimental technique, and then give a talk about their own research to demonstrate how the technique helps to address neuroscience questions. The workshop series is designed to cover a wide range of theoretical and experimental techniques and to elucidate how different techniques can be applied to answer different types of neuroscience questions. Combining the technical tutorial and the research talk, the workshop series aims to promote knowledge sharing in the community and enhance in-depth discussions among students from diverse backgrounds.
Bernstein Student Workshop Series
The Bernstein Student Workshop Series is an initiative of the student members of the Bernstein Network. It provides a unique opportunity to enhance the technical exchange on a peer-to-peer basis. The series is motivated by the idea of bridging the gap between theoretical and experimental neuroscience by bringing together methodological expertise in the network. Unlike conventional workshops, a talented junior scientist will first give a tutorial about a specific theoretical or experimental technique, and then give a talk about their own research to demonstrate how the technique helps to address neuroscience questions. The workshop series is designed to cover a wide range of theoretical and experimental techniques and to elucidate how different techniques can be applied to answer different types of neuroscience questions. Combining the technical tutorial and the research talk, the workshop series aims to promote knowledge sharing in the community and enhance in-depth discussions among students from diverse backgrounds.
Bridging the gap between artificial models and cortical circuits
Artificial neural networks simplify complex biological circuits into tractable models for computational exploration and experimentation. However, the simplification of artificial models also undermines their applicability to real brain dynamics. Typical efforts to address this mismatch add complexity to increasingly unwieldy models. Here, we take a different approach; by reducing the complexity of a biological cortical culture, we aim to distil the essential factors of neuronal dynamics and plasticity. We leverage recent advances in growing neurons from human induced pluripotent stem cells (hiPSCs) to analyse ex vivo cortical cultures with only two distinct excitatory and inhibitory neuron populations. Over 6 weeks of development, we record from thousands of neurons using high-density microelectrode arrays (HD-MEAs) that allow access to individual neurons and the broader population dynamics. We compare these dynamics to two-population artificial networks of single-compartment neurons with random sparse connections and show that they produce similar dynamics. Specifically, our model captures the firing and bursting statistics of the cultures. Moreover, tightly integrating models and cultures allows us to evaluate the impact of changing architectures over weeks of development, with and without external stimuli. Broadly, the use of simplified cortical cultures enables us to use the repertoire of theoretical neuroscience techniques established over the past decades on artificial network models. Our approach of deriving neural networks from human cells also allows us, for the first time, to directly compare neural dynamics of disease and control. We found that cultures e.g. from epilepsy patients tended to have increasingly more avalanches of synchronous activity over weeks of development, in contrast to the control cultures. Next, we will test possible interventions, in silico and in vitro, in a drive for personalised approaches to medical care. This work starts bridging an important theoretical-experimental neuroscience gap for advancing our understanding of mammalian neuron dynamics.
Invariant neural subspaces maintained by feedback modulation
This session is a double feature of the Cologne Theoretical Neuroscience Forum and the Institute of Neuroscience and Medicine (INM-6) Computational and Systems Neuroscience of the Jülich Research Center.
Flexible motor sequence generation by thalamic control of cortical dynamics through low-rank connectivity perturbations
One of the fundamental functions of the brain is to flexibly plan and control movement production at different timescales to efficiently shape structured behaviors. I will present a model that clarifies how these complex computations could be performed in the mammalian brain, with an emphasis on the learning of an extendable library of autonomous motor motifs and the flexible stringing of these motifs in motor sequences. To build this model, we took advantage of the fact that the anatomy of the circuits involved is well known. Our results show how these architectural constraints lead to a principled understanding of how strategically positioned plastic connections located within motif-specific thalamocortical loops can interact with cortical dynamics that are shared across motifs to create an efficient form of modularity. This occurs because the cortical dynamics can be controlled by the activation of as few as one thalamic unit, which induces a low-rank perturbation of the cortical connectivity, and significantly expands the range of outputs that the network can produce. Finally, our results show that transitions between any motifs can be facilitated by a specific thalamic population that participates in preparing cortex for the execution of the next motif. Taken together, our model sheds light on the neural network mechanisms that can generate flexible sequencing of varied motor motifs.
Parametric control of flexible timing through low-dimensional neural manifolds
Biological brains possess an exceptional ability to infer relevant behavioral responses to a wide range of stimuli from only a few examples. This capacity to generalize beyond the training set has been proven particularly challenging to realize in artificial systems. How neural processes enable this capacity to extrapolate to novel stimuli is a fundamental open question. A prominent but underexplored hypothesis suggests that generalization is facilitated by a low-dimensional organization of collective neural activity, yet evidence for the underlying neural mechanisms remains wanting. Combining network modeling, theory and neural data analysis, we tested this hypothesis in the framework of flexible timing tasks, which rely on the interplay between inputs and recurrent dynamics. We first trained recurrent neural networks on a set of timing tasks while minimizing the dimensionality of neural activity by imposing low-rank constraints on the connectivity, and compared the performance and generalization capabilities with networks trained without any constraint. We then examined the trained networks, characterized the dynamical mechanisms underlying the computations, and verified their predictions in neural recordings. Our key finding is that low-dimensional dynamics strongly increases the ability to extrapolate to inputs outside of the range used in training. Critically, this capacity to generalize relies on controlling the low-dimensional dynamics by a parametric contextual input. We found that this parametric control of extrapolation was based on a mechanism where tonic inputs modulate the dynamics along non-linear manifolds in activity space while preserving their geometry. Comparisons with neural recordings in the dorsomedial frontal cortex of macaque monkeys performing flexible timing tasks confirmed the geometric and dynamical signatures of this mechanism. Altogether, our results tie together a number of previous experimental findings and suggest that the low-dimensional organization of neural dynamics plays a central role in generalizable behaviors.
Theory of recurrent neural networks – from parameter inference to intrinsic timescales in spiking networks
Finding the needle in the haystack – Functional circuit and network models for neuroscience
Start of the talk will be 17:15h (CEST). This session is a double feature of the Cologne Theoretical Neuroscience Forum and the BCCN Berlin.
Generalizing theories of cerebellum-like learning
Since the theories of Marr, Ito, and Albus, the cerebellum has provided an attractive well-characterized model system to investigate biological mechanisms of learning. In recent years, theories have been developed that provide a normative account for many features of the anatomy and function of cerebellar cortex and cerebellum-like systems, including the distribution of parallel fiber-Purkinje cell synaptic weights, the expansion in neuron number of the granule cell layer and their synaptic in-degree, and sparse coding by granule cells. Typically, these theories focus on the learning of random mappings between uncorrelated inputs and binary outputs, an assumption that may be reasonable for certain forms of associative conditioning but is also quite far from accounting for the important role the cerebellum plays in the control of smooth movements. I will discuss in-progress work with Marjorie Xie, Samuel Muscinelli, and Kameron Decker Harris generalizing these learning theories to correlated inputs and general classes of smooth input-output mappings. Our studies build on earlier work in theoretical neuroscience as well as recent advances in the kernel theory of wide neural networks. They illuminate the role of pre-expansion structures in processing input stimuli and the significance of sparse granule cell activity. If there is time, I will also discuss preliminary work with Jack Lindsey extending these theories beyond cerebellum-like structures to recurrent networks.