Topic: [11C]-(+)-PHNO

False percepts induced by sensory conditioning are a promising laboratory model for hallucinations and similar illusory phenomena, with links to both clinical symptoms and neurobiological features of psychosis. The aim of the present study was to investigate the relationship between extracellular dopamine levels, as quantified by the dopamine D2/3 receptor agonist ligand [11C]-(+)-PHNO, and confidence with which conditioned auditory percepts are reported.To this end, ten healthy volunteers (2m, 8f) completed a cross-modal sensory conditioning task after undergoing a bolus plus constant infusio

Dopamine dysregulation and altered energy metabolism are established features of schizophrenia individually linked to illness severity but also exhibiting a complex mutual relationship. How these two facets of the underlying pathophysiology contribute to the varied symptoms of the disorder is still not well understood. Given the likely systemic nature of schizophrenia, we hypothesized that combined measures of dopamine and metabolic function would prove better correlates for relevant psychopathology than either of the measures alone.This possibility was investigated in a previously published d