Positron emission tomography

…Positron emission tomography data were collected from 20 healthy volunteers using the radioligand [carbonyl-11C]WAY-100635 [2,3]. Data were quantified using multilinear reference tissue model 2 to obtain non-displaceable

False percepts induced by sensory conditioning are a promising laboratory model for hallucinations and similar illusory phenomena, with links to both clinical symptoms and neurobiological features of psychosis. The aim of the present study was to investigate the relationship between extracellular dopamine levels, as quantified by the dopamine D2/3 receptor agonist ligand [11C]-(+)-PHNO, and confidence with which conditioned auditory percepts are reported.To this end, ten healthy volunteers (2m, 8f) completed a cross-modal sensory conditioning task after undergoing a bolus plus constant infusio

…Positron Emission Tomography, Single Photon Emission Computed Tomography, and Magnetic Resonance imaging are the most common methods used. They are costly, which limits their use in routine screening. We used flu

Dopamine dysregulation and altered energy metabolism are established features of schizophrenia individually linked to illness severity but also exhibiting a complex mutual relationship. How these two facets of the underlying pathophysiology contribute to the varied symptoms of the disorder is still not well understood. Given the likely systemic nature of schizophrenia, we hypothesized that combined measures of dopamine and metabolic function would prove better correlates for relevant psychopathology than either of the measures alone.This possibility was investigated in a previously published d

…quantifying molecular targets in positron emission tomography (PET). As an alternative to computed tomography (CT), a variety of approaches utilizing magnetic resonance (MR) imaging has been implemented. Since most of these are computationally expensive (i.e. take several hours), we improved upon the MaxProb[1] algorithm for use in neuroimaging. 40 paired CTs and T1 weighted MR images from a previous study[2] were normalized to Montreal Neurological Institute space. Each CT was then segmented into air, soft tissue and bone. S

…from anatomical and functional MRI to positron emission tomography.

…Aβ plaques using a technique called positron

Cross-sectional and longitudinal multimodal brain imaging studies using positron emission tomography (PET) and magnetic resonance imaging (MRI) have provided detailed insight into the pathophysiological progression of Alzheimer’s disease. It starts at an asymptomatic stage with widespread gradual accumulation of beta-amyloid and spread of pathological tau deposits. Subsequently changes of functional connectivity and glucose metabolism associated with mild cognitive impairment and brain atrophy may develop. However, the rate of progression to a symptomatic stage and ultimately dementia varies c

Molecular imaging using Positron Emission Tomography (PET) has become a major biomedical imaging technology. Its application towards characterisation of biochemical processes in disease could enable early detection and diagnosis, development of novel therapies and treatment evaluation. The technology is underpinned by the use of imaging probes radiolabelled with short-lived radioisotopes which can be specific and selective for biological targets in vivo e.g. markers for receptors, protein deposits, enzymes and metabolism. My talk will focus on the increasing development and application of PET