Topic: 6-OHDA model

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and caudoputamen (Cp), leading to motor and non-motor symptoms. Neuroinflammation, oxidative stress, and imbalance in purinergic signaling significantly contribute to its progression. Current treatments fail to halt disease progression, necessitating novel approaches. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in alleviating PD symptoms, but its underlying mechanisms remain unclear. We investigated the effects of prolonged intermitten

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to reduced striatal dopamine and motor and non-motor symptoms. The imbalance of adenosine signaling plays a role in the pathogenesis of PD, particularly through increased A2AR and reduced A1R activity affecting D2R and D1R signaling pathways, respectively. This imbalance interferes with the reciprocal modulation of adenylate cyclase by A1R/D1R and A2AR/D2R and impairs motor control. Despite existing treatment options, there is an unmet need for new interve