Topic: acetylcholinesterase

A link between type 2 diabetes mellitus and neurodegeneration has been suggested for decades. Diabetes-associated cognitive dysfunction has been linked to chronic hyperglycemia, oxidative stress, neuroinflammation, cholinergic dysfunction, and neuronal degeneration. We investigated the neuroprotective activity of a mixture of Sclerocarya birrea, Nauclea latifolia, and Piper longum (SNP) in type 2 diabetic (T2D) rat model-induced memory impairment. Fructose and streptozotocin were used to induce T2D in male Wistar rats. Diabetic animals received distilled water, metformin (200 mg/kg), or SNP mi

Dementia, a complex, incurable clinical syndrome marked by progressive cognitive decline, encompasses various types, with Alzheimer's disease (AD) being the most prevalent. The annual increase in AD cases underscores the urgency for innovative antidementia treatments. Mansorin A (MA) and mansonone G (MG) exhibit antioxidant effects on the central nervous system. Given the close association between oxidative stress and AD pathology, MA and MG might alleviate AD-like symptoms. To investigate the anti-dementia potential of MA and MG, the promnesic, anxiolytic, and antioxidant potential of MA and