Acute ischemic stroke

Acute ischemic stroke, also referred to as a cerebrovascular accident, occurs when localized tissue faces ischemia, leading to an inability to maintain physiological conditions or even resulting in death due to the obstruction or rupture of blood vessels in the brain. The current use of rt-PA for stroke medication has a limited time frame of 3-4.5 hours and is associated with neurotoxicity. Hence, there is an urgent need to explore alternative treatments for ischemic stroke. Cinchonidine, an alkaloid derived from the bark of cinchona, has previously demonstrated anti-inflammatory and antioxida

Aims.Previous findings indicate that about 50% of acute stroke patients experience hyperglycemia and is associated with unfavorable outcomes. Current treatments for acute hyperglycemia show no significant improvement in patient outcomes, indicating the ambiguity surrounding the mechanisms through with stroke triggers hyperglycemia. The purpose of this study was to explore novel biomarkers involved in the mechanism of adverse outcomes in post-stroke hyperglycemia patients. Methods.RNA sequence was performed to compare gene expression profiles between hyperglycemia and normal-glycemia stroke pat

Introduction: Neurovascular coupling (NVC) becomes impaired upon acute ischemic stroke (AIS). NVC dysfunction is thought to be linked to the evolution of spreading depolarization (SD), that causes vasoconstriction by augmenting the synthesis of 20-HETE. Here, we demonstrate the SD-related disruption of NVC during reperfusion, and block 20-HETE production to improve NVC.Methods: C57BL/6 mice (n=41) were anesthetized with isoflurane. Cerebral blood flow (CBF) variations were captured using laser speckle contrast imaging (LASCA) or laser-Doppler flowmetry. After 10 min baseline recording, transie

Scalp acupuncture (SA) has shown potential as a treatment for acute ischemic stroke. This study investigated the effects and mechanisms of SA in rodent stroke models using systematic review, animal experiments, and analysis of peripheral responses. Subsequent animal studies confirmed the anti-inflammatory effects of SA, showing reduced TNF-α, IL-1β, IL-6 and increased IL-10 in rat stroke brains. SA enhanced neurological outcomes, as measured by the 6-point neuroscore, cylinder test, and grip strength test. Although SA's reduction in stroke infarct area was not statistically significant, it not

Acute Ischemic Stroke (AIS) is a major cause of death and disability worldwide. Mechanical thrombectomy to remove clots from cerebral vasculature represents a unique opportunity to study characteristics and biological patterns of stroke pathophysiology. There is marked heterogeneity in clots and great interest in etiological biomarkers for novel therapeutic approaches/stroke prevention strategies. We investigated expression of prototypic marker of inflammation C-reactive protein (CRP) and coagulation factor thrombin in AIS clots of different etiologies. Clots from Clotbase International regist