ADHD

A full-day online scientific and clinical meeting examines autism and ADHD in women and girls, drawing together research on presentation, recognition, diagnostic assessment and the consequences of delayed or missed diagnosis. The programme considers sex ratios and diagnostic age, autistic women’s experiences of assessment, menstrual experiences, adverse experiences before ADHD diagnosis, Black women’s experiences of diagnosis and care, antenatal support for mothers with intellectual disabilities, and the role of childhood adversity and internal distress in adult autism assessments. Researchers

…is a cardinal symptom of ADHD, I will introduce its most widely used paper-and-pencil screening tool for the general population as external validation. Following that, I will present the Load Theory of At

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adults worldwide. It often coexists with anxiety, depression or alterations in sensitivity. Patients with ADHD report sensitization to pain and the prevalence of generalized pain is higher in ADHD patients (up to 80%) compared to control population (17%) (Stray LL et al., 2013). However, the mechanisms involved remain unknown. Neuroanatomical studies confirm that attentiveness and central mechanisms involved in pain transmission use identical neural networks (i.e., the anterior cingulate cor

…the NDD subsets for ASD(N=196), ADHD(N=525), intellectual disabilities(ID, N=167), and a no-NDD sample(N=1523). The open-source package Luna was used to derive multiple sleep features, including sleep spindles, slow oscillations

…and psychiatric conditions such as ADHD, autism, anxiety or depression affect the majority of NF1 patients, and these symptom complexes are not addressed by standard therapeutic strategies. Here we employed a mouse model of NF1, the heterozygous Nf1 +/- mouse line. The initial approach invo

Dysfunctional dopaminergic neurotransmission is implicated in several pathologies, including movement disorders such as parkinsonism and psychiatric diseases, suggesting overlapping pathological mechanisms. The dopamine transporter (DAT) is a key regulator of dopamine signalling and rare disease-associated DAT variants can cause psychiatric diseases and early-onset parkinsonism. However, the pathobiological processes that link DAT dysfunction to both parkinsonism and psychiatric symptoms are unknown. To investigate this, we developed a novel mouse disease model that expresses two mutations in

…in cases of autism, schizophrenia, and ADHD. The excitation to inhibition (E:I) imbalance hypothesis posits that behaviours associated with neurodevelopmental disorders such as autism may be driven by the disturbed balance of excitation and inhibition in the cortex. We aimed to identify and characterise the effect of Neurexin-1 mutations on the E:I balance in autism-associated cortical circuits.To assess the effect of Nrxn1 alpha KO on synaptic transmission, whole-cell electrophysiological recordin

Developmental psychiatric disorders, including schizophrenia, autism, and ADHD, impose significant socio-economic burdens and reduce patients’ life expectancy by 10-20 years due to their early onset and chronic impact. While the genetic implication is evident, pinpointing the implicated risk genes and understanding their mechanisms remains challenging, particularly concerning their influence on brain circuitry formation. Research has spotlighted the 15q13.3 microdeletion in humans as strongly linked to various psychiatric manifestations, with Klf13 gene emerging as a key player in neuronal pre

Genome-wide association studies (GWAS) have identified multiple disease-associated genetic variations across different psychiatric disorders raising the question of how these genetic variants relate to the corresponding pharmacological treatments. In this talk, I will outline our work investigating whether functional information from a range of open bioinformatics datasets such as protein interaction network (PPI), brain eQTL, and gene expression pattern across the brain can uncover the relationship between GWAS-identified genetic variation and the genes targeted by current drugs for psychiatr

Mental Health problems among youth constitutes an area of significant social, educational, clinical, policy and public health concern. Understanding processes and mechanisms that underlie the development of mental health problems during childhood and adolescence requires theoretical and methodological integration across multiple scientific domains, including developmental science, neuroscience, genetics, education and prevention science. The primary focus of this presentation is to examine the relative role of genetic and family environmental influences on children’s emotional and behavioural