Topic: bidirectional optogenetic control

Optogenetics is a powerful tool that allows controlling cellular activity with light by optically activating either excitatory or inhibitory synaptic ion channels. In this project, we study the effect of simultaneous optogenetic activation and inhibition in the same cells of transgenic Drosophila larvae using dual-color organic light-emitting diodes (OLEDs). The OLEDs are patterned to sub-millimeter pixels with a high degree of light confinement, reaching optical power densities of 1 mW/mm−2, microsecond response speed and device heat‐up below 3 °C upon constant drive conditions at high bright

The spatio-temporal precision of Optogenetics is one of the main reasons for its versatile utilization within Neurosciences. Recently developed tools like BiPOLES allow bidirectional optogenetic control regarding activation and inhibition. But while the current mode of inhibition, using anion-selective channelrhodopsins proved effective when targeted to the soma of the neuron, it is yet insufficient in terminals and smaller compartments. Building upon the recent discovery of light gated potassium channels, K-BIPOLES could constitute a promising alternative with the light controlled outflow of