Topic: Cannabinol (CBN)

Neuronal Kv7 (KCNQ) voltage-gated potassium channels contribute to various neurophysiological functions (such as hearing, learning, and pain modulation), and, when mutated, cause distinct pathologies (such as hearing loss, epilepsy, and intellectual disability). Cannabidiol (CBD) is a pan-Kv7 modulator, Kv7.2/3 M-channel activator and EMA-approved antiepileptic. Yet, the potential therapeutic efficacy of similar phytocannabinoids on Kv7 channels remains to be studied. Here, we aim to investigate the pharmacology of cannabinoids structurally related to CBD, such as Δ9‑Tetrahydrocannabinol (THC)

The endocannabinoid system influences virtually all central nervous system processes: learning, memory, appetite, emotions, and more. Growing evidence suggest that modulation of the endocannabinoid system by endogenous or exogenous cannabinoids may be significant in the treatment of various diseases. Tetrahydrocannabinol (THC) is the main psychoactive substance found in cannabis has been used as a pain medication due to its sedative effect. However, a whole series of other phytocannabinoids have been isolated, such as cannabinol (CBN), cannabidiol (CBD), tetrahydrocannabivarin (THCV) and Δ9-Te