Why is the suprachiasmatic nucleus such a brilliant circadian time-keeper?
Michael Hastings · MRC Laboratory of Molecular Biology, Cambridge
Tue, Feb 8, 2022 · 15:00 UTC
Circadian clocks dominate our lives. By creating and distributing an internal representation of 24-hour solar time, they prepare us, and thereby adapt us, to the daily and seasonal world. Jet-lag is an obvious indicator of what can go wrong when such adaptation is disrupted acutely. More seriously, the growing prevalence of rotational shift-work which runs counter to our circadian life, is a significant chronic challenge to health, presenting as increased incidence of systemic conditions such as metabolic and cardiovascular disease. Added to this, circadian and sleep disturbances are a recogni