Topic: cell death

Neonatal hypoxia-ischemia (HI), restricted oxygenation and reduced cerebral bloodflow to the brain is a significant cause of neonatal morbidity and mortality. Therapeutic Hypothermia (TH) is the only licensed treatment for HI, however, 40% of TH-treated neonates still develop neurodevelopmental disabilities. Curcumin induces powerful antioxidant activity, with evidence of significant neuroprotection in a neonatal HI mouse model. However, curcumin has limited therapeutic usage due to poor bioavailability and aqueous insolubility. This study aimed to: i) compare free synthetic vs natural curcumi

Microglia are the resident immune cells of the central nervous system and play a vital role in cytoprotection by maintaining brain homeostasis via direct interaction and/or secretion of molecules and vesicles with neurons, other brain cells, and even themselves. Extracellular vesicles are involved in cell-to-cell communication by transporting bioactive molecules, such as miRNAs, to recipient cells. microRNAs (miRNAs) are small noncoding RNAs that contribute to gene expression by silencing mRNAs, and it has been demonstrated that the content of the small extracellular vesicles includes miRNAs.

Cerebral hypoperfusion (CH) is a contributing factor to impairments observed in individuals diagnosed with Alzheimer's disease, vascular dementia and the elderly population. CH-induced brain damage is closely associated with oxidative stress (OS), manifested through disturbed prooxidative/antioxidative balance (PAB) within cells. Elevated levels of xanthine oxidase (XOD) are identified as a potential causal factor of OS, ultimately culminating in cell death. We aimed to investigate the protective effects of the hormone progesterone (P4) against CH‐induced OS and neurodegenerative pathologies i