Topic: cell therapy

Aim: Spinal cord injury (SCI) triggers inflammatory response by activation and accumulation radical oxygen species (ROS). Cell therapy has no effective long term recovery outcomes due to presence of ROS in lesion site increase the death rate of transplanted cells.One efficient approach to address this issue is adding adjuvants like neurotrophic factors and antioxidants, among them melatonin has been reported to play a key role in neuroprotectection. The melatonergic treatment is remarkably associated with scavenger oxidative stress and cell proliferation. The purpose of this study is the impac

Neurodegenerative diseases pose significant challenges for society due to limited treatments. Among the potential therapies, cell therapy stands out as a particularly promising one. We know that bone marrow-derived cells (BMDCs) can infiltrate the brain and transdifferentiate to different cell types, or fuse, for example, with Purkinje cells. These fusion events are unusual, but they increase in some pathologies, such as multiple sclerosis. In the Experimental Autoimmune Encephalomyelitis (EAE), a mouse model of multiple sclerosis, fused cells are functional and maintain two transcriptionally