Topic: childhood adversity

Schizophrenia, a complex neuropsychiatric condition impacting 0.5-1% of adults, manifests through positive, negative, and cognitive symptoms affecting emotions, thought processes, and perception. Onset typically occurs from late adolescence to early adulthood, with genetic and early-life environmental factors implicated in its strongly neurodevelopmental origin. The dopamine system plays a central role in schizophrenia's pathogenesis, with dopamine 2 receptor antagonists as the first line of treatment since the 1950s. Numerous studies highlight abnormal dopamine functions in schizophrenia pati

Multiple risk factors contribute to the rate of atrophy in brain aging. In large population studies, we have previously shown that adverse life history, mental and cardiovascular health impact brain structure and cognition in later life, in cross-sectional investigations. Here we investigate the impact of multiple psychosocial adversities on brain structure changes in a longitudinal design using the UK Biobank dataset. Imaging-derived phenotypes (IDPs) of grey matter and measures of white matter tract integrity were analysed from two waves of data (94%: 2-3 years difference). IDPs were correct