Topic: choroid plexus

Neurodegenerative disorders have a substantial immune component, implicating both peripheral and central immune systems. Despite neuroinflammation being linked to greater dementia risk, the interaction of central and peripheral inflammatory processes to influence disease courses remain ill-understood. A key site-of-interest for this interaction is the choroid plexus. Beyond secreting cerebrospinal fluid (CSF), it has been proposed as a gateway for peripheral immune cell entry into the central nervous system (CNS). As such, increases in choroid volume measurable with structural magnetic resonan

Choroid plexus (ChP) is located in cerebral ventricles, where it produces cerebrospinal fluid (CSF), forms the selective blood-CSF barrier and controls the homeostasis of the central nervous system. ChP is primarily composed of a monolayer of specialized epithelial cells producing cerebrospinal fluid. Differentiated ChP epithelial cells harbor multiple cilia on the CSF-facing surface, but their development and function are still controversial. We have delineated the sequential progression of cilia formation in the ChP epithelial cells by exploiting super-resolution microscopy techniques and mo

The choroid plexus (ChP) is a highly vascularized non-neural tissue located in the brain ventricles and is responsible for the production of a large part of the cerebrospinal fluid (CSF). In addition, the epithelial cells of the ChP synthesize neurotrophic factors and other signalling molecules into CSF and act as a blood-cerebrospinal fluid barrier. Importantly, ChP cells harbour a robust circadian oscillator that may control ChP function and may play an important role in the circuitry between brain clocks. In this study, we aimed to find out whether the ChP clock is sensitive to a robust imm

The choroid plexus produces cerebrospinal fluid (CSF) by transporting ions and water from adjacent blood vessels to the brain ventricles. The choroid plexus plays additional roles in brain development and homeostasis by secreting neurotrophic molecules and serving as a CSF-blood barrier and immune interface. Previous studies highlighted that several transporters on the epithelial cells transport water and ions into the ventricles and tight junctions of the cells are involved in the CSF-blood barrier. Yet, how the choroid plexus epithelial cells maintain the brain ventricle system and influence

Hydrocephalus is a disorder that involves accumulation of cerebrospinal fluid (CSF) in the ventricles of the brain. The incidence is significantly higher in preterm neonates, which is highly associated with intraventricular hemorrhage (IVH). The sequela of severe IVH manifests post-hemorrhagic hydrocephalus (PHH) that contributes to neurologic morbidity and mortality in preterm infants. There have been numerous animal models to study the mechanism and progression of hydrocephalus since 1913. However, we still lack an IVH-induced hydrocephalus model that accurately reflects the gestational age

The entry of peripheral immune cells into brain border areas like the choroid plexus and meningesis established, but the mechanism regulating their infiltration and functional role is not fullyunderstood. Our study sheds light on the role of serotonin in the migration of these cells and theirinvolvement in the action of selective serotonin reuptake inhibitors (SSRIs). We found thatfluoxetine (FLX), which is known to boost available serotonin, led to a higher number of immunecells found in the brain (parenchyma and borders) of socially isolated mice. By employing spatial transcriptomics and sin