Circuit mechanisms

…states are examined from molecular and circuit mechanisms through animal and human behaviour. Discussions connect experimental neuroscience with disorders of consciousness, recovery after general anaesthesia and the therapeutic potential of anaesthetic- and psychedelic-induced states. The format emphasizes unpublished findings, extended discussion, posters and interactions between trainees and established researchers. Atten

Over the past decade, neural representations have been studied from the lens of low-dimensional subspaces defined by the co-activation of neurons. However, this view has overlooked other forms of covarying structure in neural activity, including i) condition-specific high-dimensional neural sequences, and ii) representations that change over time due to learning or drift. In this talk, I will present a new framework that extends the classic view towards additional types of covariability that are not constrained to a fixed, low-dimensional subspace. In addition, I will present sliceTCA, a new t

Research in our lab focuses on the circuit mechanisms underlying sensory computation. We use the mouse retina as a model system because it allows us to stimulate the circuit precisely with its natural input, patterns of light, and record its natural output, the spike trains of retinal ganglion cells. We harness the power of genetic manipulations and detailed information about cell types to uncover new circuits and discover their role in visual processing. Our methods include electrophysiology, computational modeling, and circuit tracing using a variety of imaging techniques.

…accomplished through neural integrator circuits that enable external inputs to move a system’s population-wide patterns of neural activity along a continuous attractor. In the first portion of the talk, I will discuss our efforts to dissect the circuit mechanisms underlying a neural integrator from a rich array of anatomical, physiological, and perturbation expe

…in interoception, yet the cellular and circuit mechanisms of its involvement remain unclear. We developed a microprism-based cellular imaging approach to monitor insular cortex activity in behaving mice across different physiological need states. We combine this imaging approach with manipulations of peripheral physiology, circuit-mapping, cell type-specific and circuit-specific manipulation approaches t