Topic: mechanisms

Support basic, translational, clinical or population research on monosomy 7 AML and other rare, high-risk cytogenetic AML subtypes. Projects should address mechanisms, therapeutic vulnerabilities, biomarkers, treatment response, relapse or survivorship, producing useful diagnostic, therapeutic or trial-enabling findings. The three-year term begins 1 April 2027. Applications are due 1 December 2026 at 13:00 U.S. Eastern Time.

Dr. Davis will present a summary regarding the identification and characterization of mechanisms of homeostatic plasticity as they relate to the control of synaptic transmission. He will then provide evidence of translation to the mammalian neuromuscular junction and central synapses, and provide tangible links to the etiology of neurological disease.

When was the last time you ran into a giant? Chances are never. Almost 100 years ago, JBS Haldane posed an outwardly simple yet complex question – what is the most optimal size (for a biological system)? The living world around us contains a huge diversity of organisms, each with its own characteristic size. Even the size of subcellular organelles is tightly controlled. In absence of physical rulers, how do cells and organisms truly “know” how large is large enough? What are the mechanisms in place to enforce size control? Many of these questions have motivated generations of scientists to lo

In this talk, Dr. Eyo will his present research on microglia, the brain’s resident immune cell. After providing some background to these cells, Dr. Eyo will highlight two aspects of his research. First, some of his previous work elucidating microglial dynamic activity during development as well as mechanisms regulating their demise during simulated developmental ischemia will be discussed. Second, research will be presented clarifying mechanisms underlying the interactions between microglia and neurons with a special focus on seizure disorders. Together, these findings highlight microglia as a