AMIA’s 2026 Annual Symposium examines how informatics can help health systems learn from data and improve patient outcomes. Its programme connects clinical informatics, translational bioinformatics and clinical research informatics through peer-reviewed papers, panels, workshops and posters. Topics include ambient AI, clinical decision support, real-world evidence, implementation science and governance, with attention to evaluating clinical data and translating research into individual and population care. Participants include clinicians, researchers, computer scientists, health IT specialists