Topic: condensates

The second edition of this meeting examines RNA-binding proteins from posttranscriptional regulation to the regulation of protein function by RNA. New experimental and analytical methods have revealed previously unrecognised protein classes and binding modes, raising questions about how RNA interactions affect cellular activity. The programme considers structural studies, RNA conformational flexibility, condensates, metabolism, cell biology and human disease. Emerging technologies, computational analysis and AI-based modelling connect classical RNA-binding proteins with newly identified intera

Biologists have recently come to appreciate that eukaryotic cells are home to a multiplicity of non-membrane bound compartments, many of which form and dissolve as needed for the cell to function. These dynamical “condensates” enable many central cellular functions – from ribosome assembly, to RNA regulation and storage, to signaling and metabolism. While it is clear that these compartments represent a type of separated phase, what controls their formation, how specific biological components are included or excluded, and how these structures influence physiological and biochemical processes re