Protein quality control across compartments

How do cells recognise and resolve protein-folding problems in the right place and at the right time? This EMBO Workshop explores the molecular mechanisms and spatial organisation of protein quality control, from nascent chains leaving the ribosome to proteins crossing organelle boundaries or entering biomolecular condensates. Topics include co-translational folding and complex assembly, the organisation and evolution of chaperone networks, nuclear and mitochondrial surveillance, membrane-protein biogenesis, protein-lipid interactions and how substrate recognition routes aberrant proteins to refolding, disaggregation or degradation. Structural, single-molecule, live-cell, proteome-wide and computational approaches link individual molecular machines to cellular responses and to disease-associated proteostasis failure and pharmacological chaperones. Short talks are selected from abstracts, with three poster sessions; registration includes five nights at Torre Cintola near Monopoli.