Topic: cynomolgus monkeys

As part of the preclinical development for novel pharmaceuticals that target the Central Nervous System, regulatory authorities often request an assessment of potential adverse effects on cognitive function.In this study, we examined cognitive function in a group of eight naïve male cynomolgus monkeys using an automated touch screen device (mCANTAB). The aim was to assess its use under regulatory toxicity study conditions, and to characterize its performance in comparison to the Wisconsin General Test Apparatus methodology for object discrimination (Rose et al., 2015). Secondly, we investigate

By applying electrical stimulation, retinal prostheses aim to bypass dysfunctional photoreceptors and directly activate retinal ganglion cells (RGCs). Therefore, effective modulation of RGCs is the key step in the development of retinal prostheses. Six cynomolgus monkeys were used: three as a control and the other three as an N-methyl-N-nitrosourea (MNU)-induced retinal degeneration model. The retinal recording was performed using the 8x8 multi-electrode array. Figure shows the electrical stimulation pulses (a), raster plots of RGC spikes (b), and the modulation efficiency score (MES) (c). The