Energy metabolism

Investigate the energy metabolism and physiology of methane-producing archaea adapted to alkaline environments. The four-year doctoral project contributes to research on the conditions supporting life's emergence.

AIMS: The activation of CB1 receptor (CB1R) is reported to favor energy accumulation and promote resiliency against stress. The aim of this study is to elucidate whether CB1R expression in CaMKII+ neurons is sufficient to restore its role in the regulation of energy metabolism and contingent behaviors.METHODS: To this end, we applied a genetic strategy to reconstitute CB1R expression at endogenous levels in CaMKII+ neurons (CaMKII-CB1-RS).RESULTS: The rescue of CB1R expression in these neurons promotes feeding behavior causing fasting-induced hyperphagia, increased motivation and impulsivity t

…3 (ω3) ratio, have various effects on energy metabolism, neuroinflammation and behavior. Mice were fed either a control diet or a high fat diet (HFD) containing either low (LO), medium (ME) or high (HI) ω6/ω3 ratio. Mice from the HFD-LO group consumed less calories and exhibited less body weight gain compared

…that mitochondrial dysfunction and energy metabolism dysregulation may contribute to the pathophysiology of schizophrenia [1]. Therefore, we studied the mRNA expression of the prefrontal cortex (PFC) using the CommonMind data set [2] to find out if there is a significant enrichment of differentially expressed metabolism genes between control group and schizophrenia patients. In additi

…via a disruption of glucose and energy metabolism in the brain, accompanied by oxidative stress and a concurrent impact on cognitive function. The aim of this study is to evaluate the behavioral results of once or twice injections of the ICV STZ administration methods. ICV guide cannulas were placed unil

We investigate the link between the gut microbiome and cognitive decline in Alzheimer’s disease by identifying microbial metabolites associated with (compromised) brain health and examining metabolite changes in individuals who progress from a healthy state (NL) to mild cognitive impairment (MCI) and/or Alzheimer’s disease (AD).A dataset containing representative microbial metabolites in serum was obtained from the Alzheimer’s Disease Neuroimaging Initiative. A total of 104 metabolites were analyzed. These were collected over six years from 757 individuals. Kruskal-Wallis test was employed to

Dopamine dysregulation and altered energy metabolism are established features of schizophrenia individually linked to illness severity but also exhibiting a complex mutual relationship. How these two facets of the underlying pathophysiology contribute to the varied symptoms of the disorder is still not well understood. Given the likely systemic nature of schizophrenia, we hypothesized that combined measures of dopamine and metabolic function would prove better correlates for relevant psychopathology than either of the measures alone.This possibility was investigated in a previously published d

Hypothalamus is the center of energy metabolism and feeding behavior, and several hypothalamic neurotransmitters regulate energy homeostasis. Neurosecretory protein GL (NPGL) and neurosecretory protein GM (NPGM), were discovered as a novel neuropeptide from hypothalamus in 2014, induced obese phenotype owing to increased feeding behavior and lipogenesis in rats. However, the mechanisms of energy metabolism mediated by NPGL/NPGM system has not been totally elucidated. To investigate the loss of function of NPGL/NPGM system in mammals, we have established NPGL and NPGM double knockout mice (NPGL

…toxic byproducts of the cell’s energy metabolism. In neurons, this toxicity can arise when mitochondrial ATP production stalls due to limited ADP. Under t

…that bone should be a regulator of energy metabolism and reproduction and identified a bo