Topic: enhancer function

UC Berkeley Molecular & Cell Biology seminar (Division of Genetics, Genomics & Development) by Barak Cohen of Washington University in Saint Louis on massively parallel experimental studies of enhancer function.

This lecture examines how regulatory DNA contacts its target genes through both CTCF-dependent and other mechanisms. It then considers diseases caused by disrupted enhancer function, ranging from missing elements to genomic rearrangements that alter regulatory contacts. Transposable elements are discussed as contributors to the evolution of gene regulation.