Topic: evoked potentials

Sensory prosthesis research has advanced at a rapid pace, yet standard stimulation pulse shapes have remained largely unchanged. Most prostheses typically utilize symmetric pulses to deliver electrical stimulation to peripheral nerves. Recent neurophysiological studies, however, have shown that these symmetric pulses do not always reliably evoke firings in stimulated afferents, thus impeding optimal restoration of sensory inputs to the brain. One promising strategy is the use of alternative pulse waveforms---specifically, asymmetric pulses, characterized by a brief, high-amplitude cathodic pha

High-throughput electrophysiological recordings, using multichannel silicon probes, allow simultaneous registration of neural activity from multiple brain regions. However, the difficulty of determining the precise localisation of recording sites within neural subcompartments creates challenges for data analysis and the interpretation of experimental results. While electrode localisation can be achieved to some extent by post-mortem histological reconstruction of the probes, it can be improved by real-time discrimination of the electrophysiological features of the signal: evoked potentials tri