Topic: fatty acid metabolism

Leucine rich repeat transmembrane proteins (LRRMTs) are synaptic adhesion proteins able to influence synapse development and function. LRRTM4, one of the 4 members of this protein group, is able to induce presynaptic differentiation and plays a significant role in excitatory synapse development. LRRTM4 polymorphisms have been linked to multiple neuropsychiatric diseases, but the underlying mechanisms are currently unclear. Therefore, we aimed to better understand the role of this gene for brain function by combining a battery of behavioural assays with transcriptomic and metabolomic analysis u

Metabolic regulation in the nervous system plays a pivotal role in orchestrating neuronal function and maintaining cellular homeostasis. Utilizing our RNAseq data from gain- and loss-of-function studies of embryonic neural tissue and neuronal cells, we demonstrate that the nuclear receptor NR5A2 regulates hypoxia response, glycolysis, and fatty acid metabolism. Consistently, we have previously shown that NR5A2 inhibits the proliferation and growth of glioblastoma cells and tumors, respectively. Here, we elucidate a novel mechanism whereby NR5A2 functions as a potent suppressor of HIF-1α (Hypox

Thyroid hormone (T3) plays a critical role during early brain and overall central nervous system (CNS) development, and it acts as a major regulator of CNS metabolism and mitochondrial activity.Mutations in the T3 specific receptor monocarboxylate transporter 8 (MCT8) lead to hypothyroidism condition as tough in the Allan Herndon Dudley Syndrome (AHDS), which is characterized by neurodevelopmental defects.We set up a brain organoid model resembling AHDS pathological scenario to study the neurodevelopmental defects and to screen new metabolic target to restore neuronal maturation.AHDS organoids