Seminar · Genetic Epidemiology
Cortical and subcortical grey matter micro-structure is associated with polygenic risk for schizophrenia
Eva-Maria Stauffer · University of Cambridge, Department of Psychiatry
Wed, Mar 24, 2021 · 15:00 UTC
Background: Recent discovery of hundreds of common gene variants associated with schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population. It is hypothesized that normal variation in genetic risk of schizophrenia should be associated with MRI changes in brain morphometry and tissue composition. Methods: We used the largest extant genome-wide association dataset (N = 69,369 cases and N = 236,642 healthy controls) to measure PRS for schizophrenia in a large sample of adults from the UK Biobank (Nmax = 29,878) who had multiple micro- and macro-structural MRI metrics