Topic: probabilistic tractography

Psychosis is a debilitating trans-diagnostic syndrome characterized by hallucinations and delusions (Rehm and Shield 2019). The thalamus and its cortical connections play a crucial role in the pathophysiology of psychosis (Onofrj et al. 2023; Moustafa et al. 2017). However, despite often referred to as one structure, the thalamus is composed of separate nuclei with distinct cortical connections (Sherman and Guillery 2006). Recent investigations revealed lower volumes of only the medial thalamic subnuclei in first-episode psychosis patients (Thalhammer et al., 2023, in revision). Correspondingl

Schizophrenia is a debilitating psychiatric disorder presenting with delusions, hallucinations, and cognitive dysfunction, characterised by widespread aberrant connectivity both in early and chronic stages. One of the relatively most connected forebrain regions is the claustrum, which has been shown to have reduced volume in schizophrenia. However, whether claustrum microstructure and connectivity are altered remains unknown. We hypothesized aberrant claustrum structure and tract-based connectivity in individuals with recent-onset schizophrenia. Structural and diffusion-weighted MRI data from

The activity of thalamocortical neurons is largely defined by their excitatory inputs. The key determinants of excitatory afferents are the origin, complexity, and density of axon terminals. While some quantitative data are available on these aspects of glutamatergic afferents in animals, organization of excitatory inputs is unknown in the human thalamus. In this study we determined the origin, size and density of glutamatergic axon terminals in the anterior part of the human thalamus, examined their inter- and intra-nuclear heterogeneity as well and s the interindividual variability. We used