Topic: genetic change

This lecture traces research on the mouse T locus and the Tbxt gene before examining a proposed mechanism of tail loss in apes. A repeated DNA insertion may alter splicing and protein production. The discussion asks how a small genetic change could affect development and generate a large, persistent evolutionary transformation.

Tail development provides a case study for connecting genetic change to the evolution of anatomy. This lecture introduces relevant ideas from evolutionary developmental biology and RNA splicing, then considers variation in tail presence and length across mammals. It also examines what different experimental approaches can establish about DNA, form and function.