Mechanisms of drug resistance and tolerance in bacteria, fungi, and cancer
Microbiology, Cancer Biology and conference by EMBL
About
This symposium compares mechanisms of drug resistance, tolerance and persistence in bacteria, fungi and cancer. It explores how genetic change, non-genetic cellular plasticity, biochemistry and metabolism combine to let cells survive treatment. Themes include evolution under drug pressure, genome plasticity, stress responses, cellular fitness and the ecological context of drug responses.
Efflux, microenvironmental effects and other extracellular contributors are considered alongside cellular states and biochemical mechanisms. By comparing systems across species, the programme aims to deepen understanding of clonal evolution and single-cell biology and inform strategies for tackling drug resilience.
Topics
- drug resistance
- genetic change
- non-genetic cellular plasticity
- genome plasticity
- stress responses
- cellular fitness
- Efflux
- clonal evolution
People
Tel Aviv University, Israel
The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, USA
University of Turin, Italy
Institute of Biochemistry, Charité Universitätsmedizin Berlin, Germany