Prodromal gut dysbiosis, anhedonia and depression-like behavior in the A53T mouse model of Parkinson’s disease – the impact of social microenvironment
Olga Dubljević, Dušanka Popović, Željko Pavković, Milica Potrebić and 3 more
FENS Forum 2024
The role of dysregulated gut microbiota (GM) is widely recognized as relevant to the pathogenesis of Parkinson's disease (PD), particularly in case of non-motor symptoms such as depression and anhedonia. Most transgenic mouse models of PD, however, don’t exhibit clinically relevant dysbiosis. Here, for the first time,…