Topic: genome

Develop ARCA, a foundation model that combines crop microbiome, genome and environmental data to predict microbial community behaviour and support crop resilience. The NOAH consortium connects model development with greenhouse and field experiments. This 36–40-hour postdoctoral appointment starts in January 2027, initially for one year with a three-year extension after positive evaluation. Apply with a CV, motivation letter, two referee contacts and evidence of PhD completion or a planned defence.

Repeat-rich sequence blocks are considered major determinants for 3D folding and structural genome organization in the cell nucleus in all higher eukaryotes. Here, we discuss how megabase-scale chromatin domain and chromosomal compartment organization in adult mouse cerebral cortex is linked, in highly cell type-specific fashion, to multiple retrotransposon superfamilies which comprise the vast majority of mobile DNA elements in the murine genome. We show that neuronal megadomain architectures include an evolutionarily adaptive heterochromatic organization which, upon perturbation, unleashes p

Natural selection affects not only selected alleles, but also indirectly affects all genes near selected sites on the genome. An increasing body of evidence suggests that this linked selection is an important driver of evolutionary dynamics throughout the genomes of many species, implying that we need to substantially revise our basic understanding of molecular evolution. This session brings together early-career researchers working towards a quantitative understanding of the prevalence and effects of linked selection.