Dissecting the 3D regulatory landscape of the developing cerebral cortex with single-cell epigenomics
Wednesday, March 2, 2022
17:00 UTC
Boyan Bonev, PhD
Ludwig-Maximilians-Universität München
Recording
Open recording
Hosted by Neuroepigenetics Series60 minutes
Abstract
Understanding how different epigenetic layers are coordinated to facilitate robust lineage decisions during development is one of the fundamental questions in regulatory genomics. Using single-cell epigenomics coupled with cell-type specific high-throughput mapping of enhancer activity, DNA methylation and the 3D genome landscape in vivo, we dissected how the epigenome is rewired during cortical development. We identified and functionally validated key transcription factors such as Neurog2 which underlie regulatory dynamics and coordinate rewiring across multiple epigenetic layers to ensure robust lineage specification. This work showcases the power of high-throughput integrative genomics to dissect the molecular rules of cell fate decisions in the brain and more broadly, how to apply them to evolution and disease.
Topics
Related Seminars
SeminarSeminar
The Genome Remembers: Beyond the Genetic Code
Shiv Grewal discusses how chromatin and epigenetic mechanisms establish, maintain, and transmit genome states beyond the DNA sequence itself. This NIH Wednesday Afternoon Lecture Series event is…
Upcoming · Sep 16, 2026
NIH Wednesday Afternoon Lecture Series
Building a Brain, One Cell at a Time: Reading the Developmental Instructions Behind Human Neural Diversity
Tom Nowakowski explains lineage barcoding and single-cell sequencing approaches for reconstructing neural stem-cell family trees and early wiring programs in developing mouse and human brains.
Upcoming · Oct 7, 2026
Simons Center for the Social Brain at MIT
Related Job Opportunities
JobJobJob
PhD Studentship: Mitochondrial Metabolism and Novel Therapeutic Strategies for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (Fixed Term)
Supervisors: Professor Andrew Murray, Department of Physiology, Development and Neuroscience, University of Cambridge Dr Ross Lindsay, Novo Nordisk Funding: Fully funded PhD studentship (Home/UK…
Posted Aug 10, 2026
Research Associate (Fixed Term)
We seek a highly motivated Postdoctoral Research Associate to join the laboratory of Professor Kathy Niakan. We are based in the Loke Centre for Trophoblast Research (LCTR), in the Department of…
Posted Aug 11, 2026
Postdoctoral Scientist - Sarvestani Lab
The Sarvestani Lab at Cornell University is recruiting a postdoctoral scientist in systems neuroscience to study how visual and motor systems across the brain and body support perception and…
Posted Aug 12, 2026
Ithaca, New York, United States