Topic: gliomas

Gliomas are brain tumors formed by networks of connected tumor cells, nested in and interacting with neuronal networks. Neuronal activities interfere with tumor growth and occurrence of seizures affects glioma prognosis, while the developing tumor triggers seizures in the infiltrated cortex. Oncometabolites produced by tumor cells and neurotransmitters affect both the generation of epileptic activities by neurons and the growth of glioma cells through synaptic-related mechanisms, involving both GABAergic / Chloride pathways and glutamatergic signaling. From a clinical sight, epilepsy occurrenc

Introduction: Early diagnosis and classification of brain tumours are crucial to enable decisive early treatment and improve patient outcomes. Misdiagnosed brain malignancies can result in incorrect medical interventions, reducing patient survival. Computer-aided diagnostic systems incorporated with artificial intelligence techniques can be used as a robust clinical decision support system to improve brain tumour diagnosis. Aim: We aim to develop an artificial intelligence algorithm to classify MRI images into different brain tumours. Methodology: We used 7022 T1-weighted MRI scans compri

WNT signaling is aberrantly activated in human tumors including gliomas. Promoter methylation and expression of WNT pathway’s negative regulators, DKK1 and DKK3, and positive, GSK3β, together with two signaling antagonists, SFRP1 and SFRP3, were investigated in human gliomas. Gliomas, paired blood and FFPE slides were collected with patients’ consents and classified according to WHO guidelines. Methylation-specific-PCR was used for promoter analyses, while immunohistochemistry and semi-quantitative score for consequent protein expressions. Different promoter methylation frequencies were observ