Topic: global cerebral ischemia

Neurological prognosis for comatose patients resuscitated after cardiac arrest remains challenging. Functional imaging suggests that altered connectivity of the brain’s default mode network (DMN) could predict poor outcomes. Unfortunately, functional imaging is not easily applicable at the bedside.We proposed a neurophysiological method that assesses DMN function by computing the default EEG reactivity (DER). The method maps continuous EEG to a sequence of recurring oscillatory patterns termed macrostates. We labelled the default EEG macrostate (DEM) as the macrostate with the lowest probabili

Global cerebral ischemia (GCI) causes extensive neuronal injury and significant behavioural impairments. Although these sequelae can be mitigated by selective activation of estrogen receptors (ERs), their influence on inflammatory processes mediated by microglial activation are not fully understood. This study characterized the impact of selective ER activation on post-ischemic anxiety-like behaviours and microglial activation. 46 adult female Wistar rats were ovariectomized and, starting the following day, received daily subcutaneous injections of propylpyrazole triol (ERα agonist), diarylpro