Topic: immunohistochemistry

The distribution of pathological tau in the brain of patients with AD is highly predicable, and as disease worsens, it spreads transynaptically from initial regions of vulnerability. The reason why only some neurons are vulnerable to the accumulation and propagation of pathological forms of tau, and the mechanisms by which tauopathy spreads through the brain are not well understood. Using a combination of immunohistochemistry and computational analysis we have examined pathway differences between vulnerable and resistant neurons. How tau spreads across a synapse has been examined in vitro usin

Aim: Spinal cord injury (SCI) triggers inflammatory response by activation and accumulation radical oxygen species (ROS). Cell therapy has no effective long term recovery outcomes due to presence of ROS in lesion site increase the death rate of transplanted cells.One efficient approach to address this issue is adding adjuvants like neurotrophic factors and antioxidants, among them melatonin has been reported to play a key role in neuroprotectection. The melatonergic treatment is remarkably associated with scavenger oxidative stress and cell proliferation. The purpose of this study is the impac