Topic: inflammatory cytokines

Polycystic ovary syndrome (PCOS) stands out as the most prevalent reproductive disorder affecting women, impacting hormonal and metabolic equilibrium. It can manifest as hyperandrogenism, insulin resistance, anovulation, and infertility. PCOS is associated with various symptoms such as obesity, hirsutism, and acne, which, in turn, elevate the risk of conditions like endometrioma, type 2 diabetes, cardiovascular disease, and irritable bowel syndrome. Previous data from our research indicated that PCOS accelerates pain perception in patients, yet the underlying mechanism remains elusive.In this

Age and sex are major risk factors in Alzheimer’s disease (AD) with a higher incidence of the disease in females. Chronic microglial activation and dysregulated neuro-inflammation are features of AD and may contribute to disease pathogenesis in a sexually dimorphic manner. We investigated sex differences in microglia in the APP/PS1 mouse model of Alzheimer’s disease and in post mortem brain tissue from patients with Alzheimer’s disease. Here we report elevated levels of activated, iron-laden and dystrophic microglia in the cortex and hippocampus of female APP/PS1 mice, and in post mortem tissu