Enhanced simulations of whole-brain dynamics using hybrid resting-state structural connectomes
Thanos Manos, Sandra Diaz-Pier, Igor Fortel, Ira Driscoll, Liang Zhan, Alex Leow · Bernstein Conference 2024
The human brain, composed of billions of neurons and synaptic connections, is an intricate network coordinating a sophisticated balance of excitatory and inhibitory activity between brain regions. The dynamical balance between excitation and inhibition is vital for adjusting neural input/output relationships in cortical networks and regulating the dynamic range of their responses to stimuli. To infer this balance using connectomics, we recently introduced a computational framework based on the Ising model, first developed to explain phase transitions in ferromagnets, and proposed a novel hybri