Topic: Kynurenine

Orthotopic xenograft studies strongly promote the development of personalized and targeted cancer therapies to increase the still very poor life expectancy of glioblastoma (GBM) patients. As the tumor microenvironment (TME) plays an active role in cancer progression, the TME has increasingly become subject of investigations recently.We aimed to assess the metabolome from interstitial fluid (ISF) collected with Open Flow Microperfusion (cOFM) from the TME and compare it to the metabolome from cerebrospinal fluid (CSF). This was done via atraumatic access that has been generated by inoculating m

Major Depressive Disorder (MDD) is a high-prevalence neuropsychiatric condition characterized by depressed mood and anxiety. The risk of suffering MDD is higher in people with obesity and metabolic dysregulation. We will evaluate the effect of a high-fat diet (HFD) and the impact of gender on behavioural, neurochemical and molecular markers associated with depression/anxiety.Male and female C57BL/6 mice, 6-weeks old, were given a 7-week HFD (60% fat). The behavioural tests performed were: open field test (OFT), novelty-suppressed feeding (NSF) test, sucrose preference test (SPT), and tail susp

Obesity and excessive consumption of saturated fats represent important predisposing factors to the development of neurodegenerative disorders such as Alzheimer's disease (AD) and its neuropsychiatric comorbidities. Alteration of amyloid β (Aβ) homeostasis is considered the main neuropathological feature of AD and increased levels of the oligomeric forms of this peptide have been associated with increased risk of depressive states. The exposure to obesogenic environment, such as high fat diet (HFD), seems to impair Aβ catabolic function leading to the production of its neurotoxic species. In t

Adolescence, a critical stage of development characterized by increased neuroplasticity, is marked by a significant risk for the onset of psychiatric disorders. Inflammatory events during this period may increase the risk of developing psychiatric disorders, with tryptophan metabolism playing a potential role in this process.Our goal was to investigate whether exposure to lipopolysaccharide (LPS) during adolescence impacts emotional behaviour and the inflammatory response in adult animals in a sex-specific manner. Male and female C57BL6J mice were injected at PND36 with LPS (0.1 mg/kg i.p.) or