Topic: lactate

Depression is associated with alterations in brain glucose metabolism and impairments in processes associated with the astrocyte-neuron lactate shuttle (ANLS). Within this framework, lactate emerges as a promising therapeutic avenue, demonstrating antidepressant efficacy in diverse mouse models of depression, including the forced swim test and chronic corticosterone treatment. Our study explores the impact of stress and elevated corticosterone on astrocyte-neuron metabolic coupling, examining restoration potential of lactate treatment in controlled in vitro and complex in vivo settings. Prolon

Age-related decline in brain glucose utilization might stem from noradrenergic system dysfunction, which governs brain metabolism and could play a role in age-related cognitive decline. Noradrenaline released from these neurons triggers intracellular Ca2+ and cAMP signals in astrocytes, facilitating glucose uptake, glycogen degradation, and aerobic glycolysis, producing lactate as an end-product. During heightened brain activity, lactate is transferred from astrocytes to neurons to serve as fuel. The extent to which noradrenergic regulation of brain cell metabolism is impaired in aged brains a

Energy metabolism in the brain accounts for approximately 20% of the body’s oxygen consumption being glutamatergic transmission a major contributor. To meet these energetic requirements there is a tight coupling between neurons and astrocytes. Thus, neuronal glutamatergic activity decreases astrocytic oxidative glucose metabolism in favor of glucose metabolism to lactate. Lactate released by astrocytes can be oxidatively metabolized by neurons. However, little is known about the interplay between neuronal activity and astrocytic metabolism concerning other energetic sources. Here, we made use

The brain is the most energy-demanding organ of our body in proportion to its size. Within it, neurons are the prime energy consumers, but they are not alone in the brain. While the classical view of brain energetics pointed at blood-borne glucose as the main source for neuronal energy metabolism, it is now admitted that lactate is also playing a key role. The Astrocyte-Neuron Lactate Shuttle (ANLS) in which astrocytes take up glucose from the blood, store it as glycogen, and/or convert and release it under the form of lactate, is a parallel energy source. Whether neurons preferentially use gl

The brain is one of the most active metabolic organs. Indeed, weighing 2% of total body weight, it consumes up to 20% of the energy. Most of the brain energy comes from glucose catabolism, resulting in the production of ATP and lactate. Brain lactate is mainly produced by astrocytes through a process called aerobic glycolysis, while neurons, being high oxidative cells, preferentially use mitochondrial respiration to produce ATP. In this frame, astrocytes provide lactate to neurons, in a process called astrocytes to neurons lactate shuttle. Lactate is not only important as a metabolic support i

Lactate is an important metabolite produced by astrocytes and delivered to neurons to support their energy needs in a process known as the astrocyte-neuron lactate shuttle. Emerging research during the past decade has unveiled a role of lactate as a signal capable of orchestrating critical functions ranging from neuroprotection to memory. In previous work, we found that lactate enhanced the amplitude and decay time of NMDA receptor currents (INMDAR) evoked by brief applications of glutamate and glycine. These effects were not observed when neurons were exposed to lactate receptor (HCA1) agonis