Layer 2/3 pyramidal neurons

…hypothesised to be represented by layer 2/3 pyramidal neurons. We propose that these UPEs are computed through inhibitory mechanisms involving SST and PV interneurons. A circuit model demonstrates how cortica

The UBE3A gene codes for an E3 ubiquitin ligase and is critical to ensure a proper brain function. Indeed, perturbations of UBE3A dosage or function result in pathological phenotypes. Loss of UBE3A causes the Angelman Syndrome, a severe neurodevelopmental disorder characterized by intellectual disability, motor delay and seizures, while increased UBE3A copy number or activity are strongly associated with Autism. Importantly, the molecular underpinnings of UBE3A-associated pathogenic mechanisms of neurodevelopmental disorders are still poorly understood. In this project, we study the effects of

…patch clamp electrophysiology from layer 2/3 pyramidal neurons in the primary somatosensory cortex in vivo to investigate whether sensory information is dynamically encoded in cortical neurons. First, the plasticity of sensory encoding was tested by repetitive tactile stimulation delivered to the forepaw. Here, sensory encoding wa

…has been found in the activity of pyramidal neurons in layer 2/3 of diverse cortical areas. To make contextually appropriate predictions in a stochastic environment, th