How to Make a Difference: Part 1
Psychologist Martin Seligman joins Hidden Brain to discuss learned helplessness and why some people act on opportunities while others believe their actions cannot change outcomes. The conversation examines how interpretations of setbacks influence later behaviour and how optimism can help people recover a sense of agency. Seligman is a professor of psychology at the University of Pennsylvania. Hosted by Shankar Vedantam and published by Hidden Brain Media on 21 September 2026, this is the first part of How to Make a Difference. The official episode page provides a public audio player.
How Brain Circuits Function in Health and Disease: Understanding Brain-wide Current Flow
Dr. Rajan and her lab design neural network models based on experimental data, and reverse-engineer them to figure out how brain circuits function in health and disease. They recently developed a powerful framework for tracing neural paths across multiple brain regions— called Current-Based Decomposition (CURBD). This new approach enables the computation of excitatory and inhibitory input currents that drive a given neuron, aiding in the discovery of how entire populations of neurons behave across multiple interacting brain regions. Dr. Rajan’s team has applied this method to studying the neural underpinnings of behavior. As an example, when CURBD was applied to data gathered from an animal model often used to study depression- and anxiety-like behaviors (i.e., learned helplessness) the underlying biology driving adaptive and maladaptive behaviors in the face of stress was revealed. With this framework Dr. Rajan's team probes for mechanisms at work across brain regions that support both healthy and disease states-- as well as identify key divergences from multiple different nervous systems, including zebrafish, mice, non-human primates, and humans.