Topic: locomotor control

Gait ataxia is one of the most common and impactful consequences of cerebellar dysfunction. Purkinje cells, the sole output neurons of the cerebellar cortex, are often involved in the underlying pathology, but their specific functions during locomotor control in health and disease remain obfuscated. We aimed to describe the effect of gradual adult-onset Purkinje cell degeneration on gaiting patterns in mice, and to determine whether two different mechanisms that both lead to Purkinje cell degeneration cause different patterns in the development of gait ataxia. Using the ErasmusLadder together

To position his feet correctly on the wire, tightrope walker needs precise sensory feedback. This skilled motor behaviour requires the rapid integration of external sensory input to achieve accuracy in foot placement while keeping the balance. Neurones in contact with the cerebrospinal fluid (CSF-cNs), localized around the medullo-spinal central canal in all vertebrates, are GABAergic and selectively express PKD2L1 channel (Polycystin Kidney Disease 2-like1), a member of TRP superfamily, with chemo/mechanosensitive properties. In zebrafish, CSF-cNs respond to spinal cord bending and modulat