Metabolic homeostasis

…action potentials to maintain metabolic homeostasis. We propose that in PD, such metabolically re

Behaviourally relevant sensory input is routinely transmitted and processed in biological networks, despite perpetual perceptually unrelated external, and spontaneously generated internal activity. Such activity has traditionally been understood as noise. In feed-forward networks, such noise can pose a challenge, because disambiguating stimulus-evoked activity and noise in deeper layers becomes increasingly difficult, for example in pattern classification tasks. On the other hand, the beneficial effects of noise for stochastic regularization and preventing co-adaptation were recognized in deep

…action potentials that serve metabolic homeostasis called `metabolic spikes' which can

Gut-derived signals regulate metabolism, appetite, and behaviors important for mental health. We have performed a large-scale multidimensional screen to identify gut hormones and nutrient-sensing mechanisms in the intestine that regulate metabolism and behavior in the fruit fly Drosophila. We identified several gut hormones that affect fecundity, stress responses, metabolism, feeding, and sleep behaviors, many of which seem to act sex-specifically. We show that in response to nutrient intake, the enteroendocrine cells (EECs) of the adult Drosophila midgut release hormones that act via inter-or

…and environmental signals, including metabolic and nutritional cues. Puberty onset is tightly bound to the state of body energy reserves, and deregulation of energy/metabolic homeostasis is often associated with alterations in the timing of puberty. However, despite recent progress in the field, our knowledge of the specific molecular mechanisms and pathways whereby our brain decode metabolic information to modulate puberty onset remains fragmentary

To function properly, the nervous system consumes vast amounts of energy, which is mostly provided by carbohydrate metabolism. Neurons are very sensitive to changes in the extracellular fluid surrounding them, which necessitated shielding of the nervous system from fluctuating solute concentrations in circulation. This is achieved by the blood-brain barrier (BBB) that prevents paracellular diffusion of solutes into the nervous system. This in turn also means that all nutrients that are needed e.g. for sufficient energy supply need to be transported over the BBB. We use Drosophila as a model sy