Metabolic syndrome

High fat diet (HFD) chronic intake induces metabolic syndrome in mice, characterized by a body weight increase and insulin resistance (IR). Furthermore, non-alcoholic fatty liver disease (NAFLD) is strongly linked to metabolic syndrome appearance. Obesity is a risk factor in the development of neurodegenerative diseases, neuropsychiatric disorders and is associated with cognitive decline. DREAM/kchip3/calsenilin (DREAM) is a multifunctional protein that belongs to the neuronal Ca2+ sensor family. Previous studies have demonstrated the relevance of DREAM in nociception and in learning and memor

…however, they are associated with metabolic side-effects that can be detrimental to a patient’s health and well-being. Patient’s taking SGAs have a three-fold increased risk of developing metabolic syndrome (MetS). MetS includes the development of type 2 diabetes, unprecedented weight gain, and dyslipidaemia. We hypothesised that SGAs disrupt mitochondrial function in the brain and periphery, and this may explain t

Metabolic Syndrome (MetS) and obesity correlate with cognitive impairment, heightening the susceptibility to cognitive decline and dementia. Noteworthy, cognitive impairment exacerbates weight management challenges in MetS, giving rise to a "cognitive decline-MetS" loop. Indeed, various cognitive and affective functions, including memory and executive functions, were found to be compromised in MetS, with underlying mechanistic pathways supporting a potential role of oxy-inflammatory signaling.Our research delves into the nuanced realm of cognitive alterations in MetS by examining the correlati

Unhealthy nutrition, such as that characterized by a westernized style, can lead to metabolic syndrome (MetS), a cluster of cardio-metabolic risk factors associated with increased incidence of cognitive dysfunction, reducing the quality of life during aging. By contrast, regular consumption of nutraceuticals may promote brain and metabolic health, with limited side effects. We investigated whether oral administration of the polyphenol rosmarinic acid (RA, 500mg/kg) might protect aged male and female C57BL/6N mice from cognitive decline and metabolic derangement upon western diet (WD, 5.28 kcal